After over a year of inactivity on this website (a downside of so much real activity in the lab, of course), I am pleased to update the site with a few new faces – welcome to Frank, Georgia and Mitch!
Fantastic news for one of our undergrad researchers: Lara has received a Rowe Scientific Foundation Vacation Award to carry out research in our lab!
Further details coming soon..
Here’s 2017 and two publications from our stable have recently come out:
- Evidence for compounds made by plants that activate the karrikin signalling pathway, first author Kelly Sun, published in Frontiers in Plant Science:
- A comprehensive review of strigolactone signalling and evolution, co-authored with Dave Nelson, Caroline Gutjahr and Tom Bennett, published in Annual Review of Plant Biology:
Well done to all involved and thanks for your help!
The building blocks of life are strangely asymmetrical. Amino acids can come in one of two kinds – left or right – that are mirror images of one another. Synthesise them chemically, and you get half of each. But for obscure reasons, living things make their proteins out of just left-handed variety. Meanwhile “natural” DNA only comes in one form – the double helix twists in a right-handed manner (D-DNA), and never to the left (L-DNA). Left-handed proteins, right-handed DNA.
But that doesn’t stop synthetic biologists from trying to tinker around with the chemicals of life. What if you could get right-handed proteins to make left-handed DNA? Well, it seems a group from Tsinghua University, Beijing have done just that (paywall, sorry). Zimou Wang et al. chemically synthesised a small DNA polymerase from a virus, using D-amino acids, and showed it could copy a short stretch of L-DNA. The reactions were painfully slow by normal standards – it seems the viral polymerase is very inefficient compared to the ones we use in the lab for PCR – but sure enough, it worked. It seems that, as expected, there is no chemical or physical reason why life should use one side hand over another. It just happens to be that way.
Who knows – if there is life elsewhere in the universe, it could be just like staring into the looking glass.